Suggestions by @randomcaster

Super Mario

as Charles Martinet in Best character each of these actors played

Spider-Man (Insomniac)

as Yuri Lowenthal in Best character each of these actors played

Captain Koons

as Christopher Walken in Best character each of these actors played

Travis Bickle

as Robert De Niro in Best character each of these actors played

Saruman

as Christopher Lee in Best character each of these actors played

Brain Gremlin

as Tony Randall in Best character each of these actors played

James Payton

as Ice Cube in Best character each of these actors played

Huey Freeman

as Regina King in Best character each of these actors played

Amethyst

as Michaela Dietz in Best character each of these actors played

Kikimora (The Owl House)

as Mela Lee in Best character each of these actors played

Homelander

as Antony Starr in Best character each of these actors played

Invincible

as Steven Yeun in Best character each of these actors played

Rick Sanchez

as Justin Roiland in Best character each of these actors played

Ellis Boyd 'Red' Redding

as Morgan Freeman in Best character each of these actors played

Ethan Hunt

as Tom Cruise in Best character each of these actors played

Mr. X

as RuPaul in Best character each of these actors played

Marge Simpson

as Julie Kavner in Best character each of these actors played

Dead Pool

as Nolan North in Best character each of these actors played

KyleBroflovski

as Matt Stone in Best character each of these actors played

Gandhi (Clone High)

as Michael McDonald in Best character each of these actors played