Suggestions by @superbat

Charlie Heaton

as Harry Osborn in Ultimate Spider-Man (2012-2022)

Dylan O'Brien

as Peter Parker in Ultimate Spider-Man (2012-2022)

Jude Law

as Loki laufeyson in Thor: God Of Thunder (2001)

William Zabka

as Jonathan Kent in Superman: The Movie (2028)

Madonna

as Harley Quinn 1990s in Batman Beyond (Season Two)

Winona Ryder

as Barbara Gordon/Batgirl 1990s in Batman Beyond (Season Two)

Michael Keaton

as Bruce Wayne/Batman 1990s in Batman Beyond (Season Two)

Alexandra Daddario

as Spiderwoman 2012/2015 in Marvel Cinematic Universe 2000's (Gender swap)

Sydney Sweeney

as Jenny Storm in Fantastic Four First Steps (Gender Swap)

Eiza González

as Rachel Richards in Fantastic Four First Steps (Gender Swap)

John Stamos

as Remy LeBeau in X-Men: Origins Wolverine (1989)

Ron Perlman

as Victor Creed in X-Men: Origins Wolverine (1989)

Robert Redford

as Ben Parker in The Spectacular Spider-Man (2001)

John Travolta

as Norman Osborn in The Spectacular Spider-Man (2001)

Greta Lee

as Dana Tan in Batman Beyond (Season Two)

Nicolas Cage

as Kal-El/Clark Kent in Batman Beyond (Season Two)

Michael Keaton

as Bruce Wayne in Batman Beyond (Season Two)

Tanner Buchanan

as Terry McGinnis in Batman Beyond (Season Two)

Mary Elizabeth Winstead

as She-Hulk (Jennifer Walters) in Avengers: Twilight (2024)

Cameron Monaghan

as Richard Darkholme in Marvel Gender-Swap Universe