Suggestions by @rustrobot

Karen Gillan

as Gideon Nav in Gideon the Ninth

Score: -19

Tom Hiddleston

as Kelsier in The Mistborn Trilogy

Score: -31

Margaret Qualley

as Vin Venture in The Mistborn Trilogy

Score: -16

Tom Hiddleston

as Dream in Gaiman's Sandman

Score: +11

Spike Jonze

as Director in Senlin Ascends

Score: -1

Maggie Smith

as The Sphinx in Senlin Ascends

Score: +3

Jackie Earle Haley

as The Red Hand in Senlin Ascends

Score: +3

Doug Jones

as Byron in Senlin Ascends

Score: +6

Zoë Kravitz

as Edith Winters in Senlin Ascends

Score: +6

Saoirse Ronan

as Marya in Senlin Ascends

Score: +1

Gina Carano

as Iren in Senlin Ascends

Score: -14

Eddie Redmayne

as Thomas Senlin in Senlin Ascends

Score: -2

Rosa Salazar

as Voleta Boreas in Senlin Ascends

Score: +6