Suggestions by @rothgar

Chris Pine

as Crossbones in 00s Marvel Universe

Score: +1

Armie Hammer

as Crossbones in 00s Marvel Universe

Score: +1

Michael Jai White

as Black Panther in 00s Marvel Universe

Score: +1

David Harbour

as Titanium Man in 00s Marvel Universe

Score: 0

Lars Mikkelsen

as Red Skull in 00s Marvel Universe

Score: +2

Chow Yun-Fat

as The Mandarin in 00s Marvel Universe

Score: +1

Alfred Molina

as Doc Ock in 00s Marvel Universe

Score: +1

Topher Grace

as Venom in 00s Marvel Universe

Score: +1

Vin Diesel

as Taskmaster in 00s Marvel Universe

Score: +1

Michael Clarke Duncan

as Kingpin in 00s Marvel Universe

Score: +1

Julian McMahon

as Doctor Doom in 00s Marvel Universe

Score: +1

Ian McKellen

as Magneto in 00s Marvel Universe

Score: +1

Willem Dafoe

as Green Goblin in 00s Marvel Universe

Score: +1

Patrick Stewart

as Professor Charles Xavier in 00s Marvel Universe

Score: +1

Emily Blunt

as Black Widow in 00s Marvel Universe

Score: -1

Djimon Hounsou

as Black Panther in 00s Marvel Universe

Score: +1

Karl Urban

as Thor in 00s Marvel Universe

Score: +1

Jensen Ackles

as Captain America in 00s Marvel Universe

Score: +1

Sam Witwer

as Iron Man in 00s Marvel Universe

Score: -1

Jennifer Garner

as Elektra in 00s Marvel Universe

Score: +1