Suggestions by @robertbarnes

Joseph Gordon-Levitt

as Raimi-Verse Spider-Man in Spider-Man: No Way Home (2021)

Score: +8

Joe Dante

as Director in Fantastic Four (1985)

Score: +3

Jeremy Irons

as Victor Von Doom in Fantastic Four (1985)

Score: +10

John Goodman

as Ben Grimm in Fantastic Four (1985)

Score: +7

Tom Cruise

as Johnny Storm in Fantastic Four (1985)

Score: +7

Jodie Foster

as Sue Storm in Fantastic Four (1985)

Score: +5

Mark Hamill

as Reed Richards in Fantastic Four (1985)

Score: +2

Robin Williams

as Reed Richards in Fantastic Four (1985)

Score: +8

Rawson Marshall Thurber

as Director in Planes, Trains, And Automobiles (2017)

Score: +1

Robert Zemeckis

as Director in Spider-Man 2 (1984)

Score: +3

Kevin Bacon

as Harry Osborn in Spider-Man 2 (1984)

Score: +1

Bill Bixby

as Curt Connors in Spider-Man 2 (1984)

Score: -2

Lily Tomlin

as Rosie Octavius in Spider-Man 2 (1984)

Score: +4

Anthony Hopkins

as Dr. Otto Octavius in Spider-Man 2 (1984)

Score: +5

Rick Moranis

as Ted Hoffman in Spider-Man 2 (1984)

Score: +2

Katherine Hepburn

as May Parker in Spider-Man 2 (1984)

Score: -1

Morgan Freeman

as Robbie Robertson in Spider-Man 2 (1984)

Score: +2

P. J. Soles

as Betty Brant in Spider-Man 2 (1984)

Score: +1

Jack Nicholson

as Norman Osborn in Spider-Man 2 (1984)

Score: +8

Lea Thompson

as Mary Jane Watson in Spider-Man 2 (1984)

Score: +4