Suggestions by @nerdsquidssafehouse

Ray Wise

as Two face in David Lynch's Batman

Kenneth McMillan

as Penguin in David Lynch's Batman

Dean Stockwell

as Riddler in David Lynch's Batman

Sheryl Lee

as Harley Quinn in David Lynch's Batman

Isabella Rossellini

as Poison Ivy in David Lynch's Batman

Dennis Hopper

as Joker in David Lynch's Batman

Benicio del Toro

as Kingpin in Wes Anderson's Spider-Man

Russ Tamblyn

as Henry Emily in How I would have run the FNAF movie

Anguirus

as The Titans in Justice League vs Godzilla vs Kong (Animated)

Ludwig Göransson

as Composer in The Island Of Doctor Moreau

T.J. Storm

as Komodo dragon man in The Island Of Doctor Moreau

John Wesley Shipp

as Jay Garrick in Fancast DC

Kate Winslet

as Mary Jane Watson in James Cameron's Spiderman

Wilford Brimley

as Otto Octavius in James Cameron's Spiderman

Brandon Routh

as Jor-El in James Gunn's DCEU fancasting

Denzel Washington

as Mother's Milk in THE BOYS [Movie - No Actors from the Show Original Actors]

Brad Garrett

as Mojo in Marvel Studios X-Men Villains

James Woods

as Mysterio in Marvel Studios Spider-Man Villains

Jackie Earle Haley

as Carnage in Marvel Studios Spider-Man Villains

Toby Jones

as Doctor Octopus in Marvel Studios Spider-Man Villains