Suggestions by @matt2

Michael B. Jordan

as Killmonger in Avengers 5: Annihilation

Score: +2

Josh Brolin

as Thanos in Avengers 5: Annihilation

Score: +3

Robert Downey Jr.

as Tony Stark in MCU RECAST

Score: -2

Willem Dafoe

as The Joker in Batman

Score: 0

Liam Neeson

as Galactus in Wanda & Silver

Score: +1

Brad Pitt

as Annihilus in Wanda & Silver

Score: 0

Andy Serkis

as Mr. Sinister in Wanda & Silver

Score: +1

Jeffrey Dean Morgan

as Kraven the Hunter in Wanda & Silver

Score: +1

Sylvester Stallone

as Molecule Man in Wanda & Silver

Score: 0

Brie Larson

as Captain Marvel in Wanda & Silver

Score: +1

Tom Hiddleston

as Loki in Wanda & Silver

Score: +1

Sebastian Stan

as Winter Soldier in Wanda & Silver

Score: +1

Anthony Mackie

as Falcon in Wanda & Silver

Score: +1

Paul Bettany

as Vision in Wanda & Silver

Score: +1

Aaron Taylor-Johnson

as Quicksilver 2 in Wanda & Silver

Score: +2

Paul Bettany

as Vision in Marvel Studios : Wiccan

Score: +2

Evan Peters

as Quicksilver in Wanda & Silver

Score: +3

Elizabeth Olsen

as Scarlet Witch in Wanda & Silver

Score: +1

Evan Peters

as Quicksilver in Spider-Man 3: Homerun

Score: +4

Marisa Tomei

as Aunt May in Spider-Man 3: Homerun

Score: +1