Suggestions by @markgalan

Emmy Rossum

as Scarlet Witch/Wanda Maximoff in Avengers: Infinity War (COMPLETE RECAST)

Score: +1

Jon Hamm

as Iron Man in Spider-Man Homecoming

Score: +1

John Malkovich

as Vulture in Spider-Man Homecoming

Score: +3

Mary-Louise Parker

as Aunt May in Spider-Man Homecoming

Score: +2

Kira Kosarin

as Michelle in Spider-Man Homecoming

Score: +3

Zachary Gordon

as Spider-Man in Spider-Man Homecoming

Score: +4

Michael Clarke Duncan

as Thanos in The MCU (2000s)

Score: 0

Samuel L. Jackson

as Nick Fury in The Avengers

Score: +1

Ben Barnes

as Loki in The Avengers

Score: +1

Chris Evans

as Hawkeye in The Avengers

Score: +1

Bridget Regan

as Black Widow in The Avengers

Score: +1

James McAvoy

as Hulk in The Avengers

Score: +1

Josh Duhamel

as Thor in The Avengers

Score: +1

Jon Hamm

as Iron Man in The Avengers

Score: +1

Chris Pine

as Captain America in The Avengers

Score: +1

Sterling K. Brown

as Lee Everett in Telltale’s The Walking Dead Season 1 (Live Action)

Score: +2

Amy Acker

as Stormfront in The Boys

Score: +1

Ashley Edner

as Amber in The Walking Dead

Score: +1

Chad Coleman

as The Deep in The Boys

Score: +2

Blake Lively

as Starlight in The Boys

Score: +3