Suggestions by @kingkaiju

Sam Worthington

as Doctor Doom in Marvel

Score: 0

Alexander Skarsgård

as Sabertooth in Marvel

Score: +1

Pedro Pascal

as Mysterio in Marvel

Score: +1

Ben Barnes

as Kraven the Hunter in Marvel

Score: +1

Jason Momoa

as Kraven the Hunter in Marvel

Score: +1

Gerard Butler

as Doctor Octopus/Doc Ock in Marvel

Score: 0

Henry Cavill

as Mister Sinister in Marvel

Score: 0

Blake Lively

as Medusa in Marvel

Score: +1

Ralph Fiennes

as Magneto in Marvel

Score: 0

Sam Claflin

as Electro in Marvel

Score: +1

Donnie Yen

as Mister Negative in Marvel

Score: +1

Robert Pattinson

as Scorpion in Marvel

Score: +1

Mechad Brooks

as Deathlok in Marvel

Score: +1

Shaun Ross

as Tombstone in Marvel

Score: 0

Nonso Anozie

as Tombstone in Marvel

Score: +3

Cillian Murphy

as (King) Cobra in Marvel

Score: +1

Tom Hopper

as Kallark/Gladiator in Marvel

Score: +1

John Boyega

as Shocker in Marvel

Score: +1

Leo Howard

as The (Green) Goblin in Marvel

Score: +1

Kiefer Sutherland

as Galactus in Marvel

Score: +1