Suggestions by @joseheroxd

Isabella Sermon

as Mary Jane Watson in Spider-Gwen (MCU Origin)

Score: +1

Sam Raimi

as Director in Spider-Man 4 - 6 (2011 - 2015)

Score: +2

Rosemary Harris

as May Parker in Spider-Man 4 - 6 (2011 - 2015)

Score: +1

Elizabeth Banks

as Betty Brant in Spider-Man 4 - 6 (2011 - 2015)

Score: +2

LL Cool J

as Herman Schultz in Spider-Man 4 - 6 (2011 - 2015)

Score: 0

Kevin Durand

as Aleksei Sytsevich in Spider-Man 4 - 6 (2011 - 2015)

Score: +3

Michael C. Hall

as Cletus Kasady in Spider-Man 4 - 6 (2011 - 2015)

Score: -1

J.K. Simmons

as John Jonah Jameson in Spider-Man 4 - 6 (2011 - 2015)

Score: +2

Gerard Butler

as Kraven in Spider-Man 4 - 6 (2011 - 2015)

Score: -1

Dylan Baker

as Curt Connors in Spider-Man 4 - 6 (2011 - 2015)

Score: +2

Bruce Campbell

as Quentin Beck in Spider-Man 4 - 6 (2011 - 2015)

Score: +3

John Malkovich

as Adrian Toomes in Spider-Man 4 - 6 (2011 - 2015)

Score: +2

Tobey Maguire

as Peter Parker in Spider-Man 4 - 6 (2011 - 2015)

Score: +2

Anne Hathaway

as Felicia Hardy in Spider-Man 4 - 6 (2011 - 2015)

Score: +3

Andrew Koji

as Attuma in Namor the Sub-Mariner

Score: +2

Laura Harrier

as Lois Lane in The Perfect Superman Movie

Score: +1

Aubrey Plaza

as Toni Stark in Gender-Swapped Avengers

Score: +1

Alison Brie

as Harley Quinn in Batman Arkham series

Score: +1

Henry Cavill

as Batman in Batman Arkham series

Score: +1

Laurence Fishburne

as Otto Octavius in Fancasting Spider-Man villains in MCU

Score: 0