Suggestions by @joeyhalgren

Ryan Reynolds

as Deadpool in MCU and DCEU actor swap

Score: +1

Ray Wise

as Hugh Jones in Kaine: Scarlet Spider

Score: +1

Charlize Theron

as Ero in Kaine: Scarlet Spider

Score: +1

George Clooney

as Mr. Moctezuma in Kaine: Scarlet Spider

Score: +1

Diego Tinoco

as Eduardo Lobo in Kaine: Scarlet Spider

Score: +1

Diego Boneta

as Carlos Lobo in Kaine: Scarlet Spider

Score: +1

Jenna Dewan

as Bella Donna Boudreaux in Kaine: Scarlet Spider

Score: +2

Julie Walters

as Madam Web in Kaine: Scarlet Spider

Score: +1

Douglas Booth

as Lt. Wally Layton in Kaine: Scarlet Spider

Score: +1

Bella Thorne

as Annabelle Adams in Kaine: Scarlet Spider

Score: +1

Jake Gyllenhaal

as Mysterio in Spider-Man: Far From Home

Score: +5

James McAvoy

as Norman Osborn in Spider-Man: Far From Home

Score: -8

Harrison Osterfield

as Harry Osborn in Spider-Man: Far From Home

Score: -15

Timothée Chalamet

as Ben Reily in Kaine: Scarlet Spider

Score: +1

Nikki SooHoo

as Aracely de las Heras in Kaine: Scarlet Spider

Score: -2

Nina Lu

as Aracely de las Heras in Kaine: Scarlet Spider

Score: -2

Jamie Bell

as Kaine Parker in Kaine: Scarlet Spider

Score: 0

Dominic West

as Roman in Batman TV

Score: 0

John Cena

as Bane in Batman TV

Score: 0

Paul Telfer

as Jace in Magic the Gathering Orgins

Score: 0