Suggestions by @giskycome

Luis Guzmán

as Hector Villanueva in Christodora

Score: +1

Henry Cavill

as Jared Traum in Christodora

Score: +1

Margot Robbie

as Milly Heyman in Christodora

Score: +1

Dacre Montgomery

as Maven in Red Queen Series

Score: -11

Ralph Fiennes

as Axel Mortmain in The Infernal Devices (trilogy)

Score: +2

Tom Holland

as Flash in Titans V Justice League

Score: -2

Helen Mirren

as Imogen Herondale in The Mortal Instruments

Score: +3

Margot Robbie

as Mystique in Female Heroines of Marvel and DC

Score: +1

Oscar Isaac

as Diego Rosales in Lord of Shadows

Score: -1

Jon Hamm

as Reverse Flash in DCEU Rebooted

Score: -1

Alexander Siddig

as Tiger in Batman

Score: 0

Jim Carrey

as The Joker in Gotham City Sirens (DCEU)

Score: -4

Idris Elba

as The Anti-Monitor in Green Lantern

Score: +1

Bill Hader

as Arthur Light in Teen Titans [Live Action Adaptation]

Score: +1

Tom Hardy

as Charles Xavier in Marvel Cinematic Universe

Score: -14

Elle Fanning

as Female Musical Artists. in The Most Attractive Celebrities

Score: +3

Bill Nighy

as M in James Bond

Score: +3

Michelle Pfeiffer

as May Parker in The perfect Spider-Man movie

Score: 0

Scarlett Johansson

as Actresses in Talent that should be in the MCU

Score: +9

Margot Robbie

as Lois Lane in Superman Fan Cast

Score: -2