Suggestions by @franrocha

Christoph Waltz

as Otto Octavius in The Amazing Spider-Man 4 (2021)

Score: +4

Jonathan Banks

as Adrian Toomes in The Amazing Spider-Man 4 (2021)

Score: +6

Momona Tamada

as Kamiya Hanaori in Samurai Sentai Shinkenger Next

Score: +2

Samuel L. Jackson

as Nick Fury in MCU 2000's

Score: -1

Tom Holland

as Spider-Boy in MCU 2000's

Score: +1

Jacob Tremblay

as Franklin Richards in MCU 2000's

Score: +2

Dafne Keen

as X-23 in MCU 2000's

Score: +1

Doug Jones

as Silver Surfer in MCU 2000's

Score: +6

Julian McMahon

as Doctor Doom in MCU 2000's

Score: +3

Rebecca Romijn

as Mystique in MCU 2000's

Score: +2

Rebecca Romijn

as Mystique in MCU 2000's

Score: +1

Rebecca Romjin

as Mystique in MCU 2000's

Score: +1

Halle Berry

as Storm in MCU 2000's

Score: +3

James Marsden

as Cyclops in MCU 2000's

Score: +2

Ian McKellen

as Magneto in MCU 2000's

Score: +2

Patrick Stewart

as Professor X in MCU 2000's

Score: +3

Mckenna Grace

as Brainstorm in MCU 2000's

Score: +2

Julia Butters

as Spider-Girl in MCU 2000's

Score: +3

Scarlett Johansson

as Black Widow in MCU 2000's

Score: -1