Suggestions by @fankid4

Joaquin Phoenix

as Ben Grimm in Fantastic Four

Score: 0

Alison Brie

as Susan Storm in Fantastic Four

Score: +1

Pedro Pascal

as Reed Richards in Fantastic Four

Score: -1

Tom Holland

as Peter Parker in Clone Saga

Score: +1

Nikolaj Coster-Waldau

as Rhino in Spider Man Season 1

Score: +1

Brady Noon

as Harry Osborn in Spider Man Season 1

Score: +1

Millie Bobby Brown

as Black Cat in Spider Man Season 1

Score: +1

Jon Hamm

as Uncle Ben in Spider Man Season 1

Score: +1

Aaron Paul

as Electro in Spider Man Season 1

Score: +1

Javon Walton

as Flash Thompson in Spider Man Season 1

Score: 0

Winona Ryder

as Aunt May in Spider Man Season 1

Score: +1

Isabella Sermon

as Mary jane in Spider Man Season 1

Score: +1

Aaron Paul

as Multiverse Venom 1 in Spiderman Season 3

Score: +1

Bill Hader

as Mulitiverse Venom 3 in Spiderman Season 3

Score: +1

Antony Starr

as Multiverse Venom 5 in Spiderman Season 3

Score: +1

Daniel Gillies

as Multiverse Venom 6 in Spiderman Season 3

Score: +1

John Cena

as Multiverse Venom 4 in Spiderman Season 3

Score: +1

Nikolaj Coster-Waldau

as Multiverse Venom 2 in Spiderman Season 3

Score: +1

Micheal Mando

as The Scorpion in Spiderman Season 3

Score: +1

The Sinister Six

as The New New Sinister Six in Spiderman Season 2

Score: +1