Suggestions by @doedoe

Jared Leto

as Morbius in MCU

Score: -2

Bryan Cranston

as Norman Osborn in MCU

Score: +1

Jason Isaacs

as Nathaniel Essex in MCU

Score: +1

Pedro Pascal

as Kravent the Hunter in MCU

Score: 0

Jeffrey Wright

as Otto Octavius in MCU

Score: -1