Suggestions by @damiankinoman

Christopher Nolan

as Betelgeuse in Beetlejuice (2021)

Score: -3

Seth MacFarlane

as John Constantine in HBO Max's Justice League Dark

Score: -8

Billie Piper

as Harleen Quinzel in Suicide Squad

Score: +1

Danai Gurira

as Amanda Waller in Suicide Squad

Score: 0

Keke Palmer

as Batgirl/Oracle in DCEU Rebooted

Score: -21

Olivia Wilde

as Domino in DeadPool 3

Score: +1

Lamorne Morris

as Weasel in DeadPool 3

Score: +1

Seth MacFarlane

as DeadPool in DeadPool 3

Score: -4

Seth MacFarlane

as Deadpool in The Avengers (Recasted)

Score: -4

Seth MacFarlane

as Cousin Itt in The Addams Family (Netflix Live Action Series)

Score: +2

Robert Maillet

as Lurch in The Addams Family (Netflix Live Action Series)

Score: +1

Aidan Gallagher

as Pugsley Addams in The Addams Family (Netflix Live Action Series)

Score: -3

Sally Hawkins

as Liane Cartman in South Park

Score: +3

Frances McDormand

as Barbara Pewterschmidt in Family Guy (2020)

Score: +1

Frances McDormand

as Barbara Pewterschmidt in Family Guy (2020)

Score: +1

Jon Favreau

as Dr. Elmer Hartman in Family Guy (2020)

Score: +1

Jennifer Lopez

as Diane Simmons in Family Guy (2020)

Score: +1

Steve Carell

as Tom Tucker in Family Guy (2020)

Score: +1

Rupert Grint

as Mort Goldman in Family Guy (2020)

Score: +1

Jennifer Aniston

as Bonnie Swanson in Family Guy (2020)

Score: +1