Suggestions by @chasestucki

Jamie Lee Curtis

as Green Goblin (Raimi) in Spider Man Movies (Genderswap) (2002-2021)

Score: +1

Michelle Pfeiffer

as Green Goblin (Raimi) in Spider Man Movies (Genderswap) (2002-2021)

Score: +1

Mila Kunis

as Harriet Osborn (Raimi) in Spider Man Movies (Genderswap) (2002-2021)

Score: +1

Joseph Gordon-Levitt

as MJ (Raimi) in Spider Man Movies (Genderswap) (2002-2021)

Score: +1

Jake Gyllenhaal

as MJ (Raimi) in Spider Man Movies (Genderswap) (2002-2021)

Score: +2

Hayden Christensen

as MJ (Raimi) in Spider Man Movies (Genderswap) (2002-2021)

Score: +1

Natalie Portman

as Spider Woman (Raimi) in Spider Man Movies (Genderswap) (2002-2021)

Score: +1

Elizabeth Banks

as Spider Woman (Raimi) in Spider Man Movies (Genderswap) (2002-2021)

Score: +1

Katie Holmes

as Spider Woman (Raimi) in Spider Man Movies (Genderswap) (2002-2021)

Score: +1

Linda Cardellini

as Spider Woman (Raimi) in Spider Man Movies (Genderswap) (2002-2021)

Score: +2

Julianne Moore

as Monica Gallagher in Shameless (Alternate Casting) (2011-2021)

Score: +1

Jamie Lee Curtis

as Monica Gallagher in Shameless (Alternate Casting) (2011-2021)

Score: +1

Amanda Seyfried

as Fiona Gallagher in Shameless (Alternate Casting) (2011-2021)

Score: +3

Grant Gustin

as Lip Gallagher in Shameless (Alternate Casting) (2011-2021)

Score: +1

Zoe Saldaña

as Veronica V Ball in Shameless (Alternate Casting) (2011-2021)

Score: +1

Channing Tatum

as Kevin Kev Ball in Shameless (Alternate Casting) (2011-2021)

Score: +1

Allison Janney

as Sheila Jackson in Shameless (Alternate Casting) (2011-2021)

Score: +1

Aaron Paul

as Jimmy Lishman in Shameless (Alternate Casting) (2011-2021)

Score: +1

Robert Pattinson

as Mickey Milkovich in Shameless (Alternate Casting) (2011-2021)

Score: +1

Zac Efron

as Mickey Milkovich in Shameless (Alternate Casting) (2011-2021)

Score: +1