Suggestions by @bajandoc

Zac Efron

as Johnny Storm in Fantastic 4

Score: -1

Annabelle Wallis

as Dr. Susan Storm in Fantastic 4

Score: +1

Samara Weaving

as Dr. Susan Storm in Fantastic 4

Score: -1

Emily Blunt

as Dr. Susan Storm in Fantastic 4

Score: -1

Dan Stevens

as Dr. Reed Richards in Fantastic 4

Score: -1

Rahul Kohli

as Dr. Reed Richards in Fantastic 4

Score: +1

John Krasinski

as Dr. Reed Richards in Fantastic 4

Score: -1

Dev Patel

as Taj Nital in Blade

Score: +1

Rahul Kohli

as Dr. Reed Richards in Fantastic 4

Score: +1

Garrett Hedlund

as Cyclops in Future MCU Characters

Score: -1

Milo Gibson

as Wolverine in Future MCU Characters

Score: +6

Jack Veal

as Kid Loki in Loki

Score: +1

Sophia Di Martino

as Sylvie Lushton in Loki

Score: +1

Wunmi Mosaku

as Hunter B-15 in Loki

Score: +1

Gugu Mbatha-Raw

as Justice Ravonna Lexus Renslayer in Loki

Score: +1

Owen Wilson

as Mobius M. Mobius in Loki

Score: +1

Henry Cavill

as Hercules Panhellenios/Harry Cleese in Thor

Score: -1

Russell Crowe

as Zeus Panhellenios in Thor

Score: +1

Sam Neill

as Asgardian Actor Odin in Thor

Score: +1

Melissa McCarthy

as Asgardian Actor Hela in Thor

Score: +1