Suggestions by @andrewsheng

Will Smith

as Irene Daniels in The Closer Genderswap

Score: +1

Constance Marie

as Julio Sanchez in The Closer Genderswap

Score: +1

Linda Hamilton

as Michael Tao in The Closer Genderswap

Score: +1

Carrie-Anne Moss

as Fritz Howard in The Closer Genderswap

Score: +1

Connie Nielsen

as Andy Flynn in The Closer Genderswap

Score: +1

Jessica Lange

as Louie Provenza in The Closer Genderswap

Score: +1

Sanaa Lathan

as Russell Taylor in The Closer Genderswap

Score: +1

Jada Pinkett Smith

as David Gabriel in The Closer Genderswap

Score: +1

Allison Janney

as Will Pope in The Closer Genderswap

Score: +1

Kevin Bacon

as Brenda Leigh Johnson in The Closer Genderswap

Score: +2

Tom Selleck

as Walter Bishop in Fringe (1998 - 2003)

Score: +2

Jamie Lee Curtis

as Nicola Wick in The Drew Carey Show genderswap

Score: +1

Charlize Theron

as Nicola Wick in The Drew Carey Show genderswap

Score: +1

Josh Gad

as Jerry Seinfeld in Seinfeld Reboot

Score: +1

Andrew Garfield

as Jerry Seinfeld in Seinfeld Reboot

Score: +1

Steve Carell

as Jerry Seinfeld in Seinfeld Reboot

Score: +1

David Tennant

as Jerry Seinfeld in Seinfeld Reboot

Score: +1

Paul Dano

as Jerry Seinfeld in Seinfeld Reboot

Score: +1

Tom Holland

as Jerry Seinfeld in Seinfeld Reboot

Score: +1

Benedict Cumberbatch

as Jerry Seinfeld in Seinfeld Reboot

Score: +1