Suggestions by @andrewsheng

Seth Rogen

as Ron Doyle in Frasier Genderswap

Score: +1

Neve Campbell

as Neve Crane in Frasier Genderswap

Score: +1

Dean Norris

as Dean Moon in Frasier Genderswap

Score: +1

Spencer Grammer

as Francine Crane in Frasier Genderswap

Score: +1

Steve Carell

as John White in Unbreakable Kimmy Schmidt Genderswap

Score: +1

Jerry Seinfeld

as Lenny Kaushtupper in Unbreakable Kimmy Schmidt Genderswap

Score: +1

Sanaa Lathan

as Tina Andromedon in Unbreakable Kimmy Schmidt Genderswap

Score: +1

Conan O'Brien

as Kenny Schmidt in Unbreakable Kimmy Schmidt Genderswap

Score: +1

Nick Jonas

as Nick Reagan-Boyle in Blue Bloods Genderswap

Score: +1

Steve Carell

as Lenny Reagan in Blue Bloods Genderswap

Score: +1

Wendy Schaal

as Francine Reagan in Blue Bloods Genderswap

Score: +1

Barbara Walters

as Harriet Reagan in Blue Bloods Genderswap

Score: +1

Anna Kendrick

as Jane Reagan in Blue Bloods Genderswap

Score: +1

Aaron Paul

as Eric Reagan in Blue Bloods Genderswap

Score: +1

Busy Philipps

as Danni Reagan in Blue Bloods Genderswap

Score: +2

Beth Behrs

as The Observer in Fringe

Score: +1

Anna Kendrick

as Lily Lincoln in Fringe

Score: +1

Kelsey Grammer

as Walter Bishop in Fringe (1998 - 2003)

Score: +1

Bruce Campbell

as Walter Bishop in Fringe (1998 - 2003)

Score: +1

Hugh Laurie

as Walter Bishop in Fringe (1998 - 2003)

Score: +1