Suggestions by @agustincardozo

Natalia Dyer

as Madonna in Madonna Biopic

Score: +1

Joe Manganiello

as Lucas Lee in Scott Pilgrim vs. the World (2000)

Score: +1

Kunal Nayyar

as Matthew Patel in Scott Pilgrim vs. the World (2000)

Score: +3

Jason Segel

as Stephen Stills in Scott Pilgrim vs. the World (2000)

Score: +1

Jon Abrahams

as Wallace Wells in Scott Pilgrim vs. the World (2000)

Score: +1

Anne Hathaway

as Stacey Pilgrim in Scott Pilgrim vs. the World (2000)

Score: +3

Anne Hathaway

as Ramona Flowers in Scott Pilgrim vs. the World (2000)

Score: +1

Anne Hathaway

as Julie Powers in Scott Pilgrim vs. the World (2000)

Score: +1

Mary Elizabeth Winstead

as Coraline Jones in Coraline (1999)

Score: +1

Bryce Dallas Howard

as Roxanne "Roxy" Richter in Scott Pilgrim vs. the World (2000)

Score: +2

Sarah Michelle Gellar

as Roxanne "Roxy" Richter in Scott Pilgrim vs. the World (2000)

Score: +3

Kal Penn

as Matthew Patel in Scott Pilgrim vs. the World (2000)

Score: +3

Constance Wu

as Knives Chau in Scott Pilgrim vs. the World (2000)

Score: 0

Kirsten Dunst

as Envy Adams in Scott Pilgrim vs. the World (2000)

Score: 0

Audrey Holcomb

as Allison Reynolds in The Breakfast Club

Score: +1

Martin McCann

as Bono Vox in Rockstars Biopics

Score: +1

Keanu Reeves

as Bono Vox in Rockstars Biopics

Score: -1

Justin Timberlake

as Bono Vox in Rockstars Biopics

Score: -1

Bengt Ekerot

as The Supernatural Anaesthetist in The Lamb Lies Down On Broadway

Score: +1

Linda Gray

as Lamia #1 in The Lamb Lies Down On Broadway

Score: +1