Suggestions by @3732pl07

Toby Stephens

as Tucker Carlson in Donald Trump (Biopic)

Score: +1

Philip Seymour Hoffman

as Sebastian Shaw in X-Men 2000s Movie Series

Score: 0

Bryan Cranston

as Dr Abraham Cornelius in X-Men 2000s Movie Series

Score: +2

James Gandolfini

as William Stryker in X-Men 2000s Movie Series

Score: +2

Scott Adkins

as Omega Red in X-Men 2000s Movie Series

Score: 0

Benicio del Toro

as Sebastian Shaw in X-Men 2000s Movie Series

Score: +2

Mickey Rourke

as Sabretooth in X-Men 2000s Movie Series

Score: 0

Harry Gregson-Williams

as Composer in Justice League (2000s)

Score: +1

Tony Shalhoub

as Dr. Bolivar Trask in X-Men (2000's) TV show

Score: +1

Christopher Lee

as Steppenwolf in Justice League (2000s)

Score: +1

Johnny Depp

as Victor Von Doom in Fantastic Four (2000's)

Score: +1

Alessandro Nivola

as Sam Raimi in Actors playing Directors

Score: +1

Phil Lord and Christopher Miller

as Super Smash Bros in Video Game Movie Directors

Score: +1

Mission: Impossible - Rogue Nation (2015)

as Final Fantasy VII in Which projects should inspire these live action adaptions of video games

Score: +1

Guardians of The Galaxy Vol. 3

as Final Fantasy VII in Which projects should inspire these live action adaptions of video games

Score: +1

Michael Clarke Duncan

as Sapper Morton in Blade Runner 2049 [2007]

Score: +2

Brian Cox

as Shockwave in Transformers One (2004 version)

Score: +1

Benicio del Toro

as Iron Man in Ultimate Universe (2000's)

Score: +1

Johnny Depp

as 2000s in What Actors Could've Played Doctor Doom in Various Decades?

Score: +2

Alfonso Cuarón

as Director in Justice League (2000s)

Score: +2